Anti-Mus81 antibody [MTA30 2G10/3] ab14387 from Abcam

Product Specs
ItemAnti-Mus81 antibody [MTA30 2G10/3]
CompanyAbcam
Price Pricing Info Supplier Page View Company Product Page
Catalog Numberab14387
Antibody TypePrimary
Quantity100 UG
HostMouse, Nude mouse
CloneMTA30 2G10/3
IsotypeIgG2a
ApplicationsFlow Cytometry, Immunoprecipitation, Western blot
ClonalityMonoclonal
Conjugate/TagUnconjugated
Concentration1 mg/ml
Gene NameMUS81
ReactivityHuman
TargetMus81

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) MUS81 cleaves TOP1-derived lesions and other DNA–protein cross-linksBMC BiologyMay 16, 2023Victoria Marini, Fedor Nikulenkov, Pounami Samadder, Sissel Juul, Birgitta R. Knudsen, Lumir Krejci(Abcam #ab4166, 1:1000 solution), anti-TOP1 (Abcam #ab109374, 1:10000 solution), anti-MUS81 (Abcam #ab14387, 1:1000 solution) and anti-Actin antibodies (Abcam #ab8226, 1:5000 solution). Supplementary Information

(2) RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forksThe Journal of cell biologyMay 1, 2023Moore CE, Yalcindag SE, Czeladko H, Ravindranathan R, Wijesekara Hanthi Y, Levy JC, Sannino V, Schindler D, Ciccia A, Costanzo V, et al.Proteintech). Mouse antibodies included BRCA1 (sc-6954; Santa Cruz), His (ab49781; Abcam), and MUS81 (ab14387; Abcam), while rat antibodies included HA (12013819001; Roche). Secondary antibodies were goat anti-rabbit

(3) Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activityNature communicationsApril 27, 2023Broderick R, Cherdyntseva V, Nieminuszczy J, Dragona E, Kyriakaki M, Evmorfopoulou T, Gagos S, Niedzwiedz W.(Sigma, HPA005848, 1:1000), MCM2 (Abcam, ab4461, 1:10,000), MRE11 (Abcam, ab214, 1:1000), MUS81 (Abcam, ab14387 1:1000), POLD3 (Abnova, H00010714-M01, 1:500), RAD52 (28045-1-AP, Proteintech, 1:2000), SMARCAL1 (Santa Cruz

(4) FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cellsCommunications biologyDecember 21, 2022Said M, Barra V, Balzano E, Talhaoui I, Pelliccia F, Giunta S, Naim V.Vinculin (Abcam ab18058), FANCD2 (Abcam ab108928), SETX (Novus Biologicals NB100-57542), MUS81 (Abcam ab14387), XPF (Invitrogen MA5-12054). Clonogenic assays Cells were plated at densities between 500 and 750

(5) Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51Nature communicationsNovember 7, 2022Heijink AM, Stok C, Porubsky D, Manolika EM, de Kanter JK, Kok YP, Everts M, de Boer HR, Audrey A, Bakker FJ, et al.(Santa Cruz, sc-365341, 1:250), SLX4 (BTBD12; Novus Biologicals, NBP1-28680, 1:1000), MUS81 (Abcam, ab14387, 1:1000), ERCC1 (Cell Signaling, 3885, 1:1000), HSP90 (Santa Cruz, sc-1055, 1:1000), and beta-Actin

(6) A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stressNature communicationsAugust 30, 2022Griffin WC, McKinzey DR, Klinzing KN, Baratam R, Eliyapura A, Trakselis MA.α-DNA2 (Invitrogen, PA5-68167), 1:100; α-EXO1 (Bethyl Laboratories, A302-640A), 1:2000; α-MUS81 (Abcam, ab14387), 1:1000; α-GAPDH (Pierce, MA5-15738), 1:20,000, α-Lamin B1 (Proteintech, 12987-1-AP), 1:5000, α-β-actin

(7) DNA replication is highly resilient and persistent under the challenge of mild replication stressCell ReportsApril 19, 2022Camelia Mocanu, Eleftheria Karanika, María Fernández-Casañas, Alex Herbert, Tomisin Olukoga, Mete Emir Özgürses, Kok-Lung ChanAB_397616 Rabbit anti-Histone H3pS10,Abcam,Cat# ab5176; RRID: AB_304763 Mouse anti-MUS81,Abcam,Cat# ab14387; RRID: AB_301167 Mouse anti-RAD52 (F-7),Santa Cruz,Cat# sc-365341; RRID: AB_10851346 Mouse anti-POLD3,Abnova,Cat#

(8) CHK1 phosphorylates PRIMPOL to promote replication stress toleranceScience advancesApril 1, 2022Mehta KPM, Thada V, Zhao R, Krishnamoorthy A, Leser M, Lindsey Rose K, Cortez D.F7425), GFP (Abcam, catalog no. ab290), HLTF (Abcam, catalog no. ab183042), MUS81 (Abcam, catalog no. ab14387), PRIMPOL (Custom, Mendez Lab), RAD51 (Abcam, catalog no. ab63801), RPA32 S4/S8 (Bethyl Laboratories,

(9) WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cellsNature communicationsNovember 12, 2021Datta A, Biswas K, Sommers JA, Thompson H, Awate S, Nicolae CM, Thakar T, Moldovan GL, Shoemaker RH, Sharan SK, et al.Santa Cruz Biotechnology, Inc., 1:2000), anti-DNA2 (ab96488, Abcam, 1:1000), anti-Mus81 (MTA30 2G10/3, ab14387, Abcam, 1:1000), anti-Rad52 (F-7, sc-365341, Santa Cruz Biotechnology Inc., 1:1000), anti-Exonuclease 1

(10) Differential Effects of Combined ATR/WEE1 Inhibition in Cancer CellsCancersJuly 28, 2021Rødland GE, Hauge S, Hasvold G, Bay LTE, Raabe TTH, Joel M, Syljuåsen RG.10 min at room temperature. Cells were stained with anti-CDC45 (sc-55569, Santa Cruz) or anti-MUS81 (ab14387, Abcam), followed by Alexa Fluor 488 anti-mouse IgG. In experiments where median values were measured,

(11) Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damageNature communicationsJuly 16, 2021Wu X, Wang B.using Lipofectamine RNAiMAX (Invitrogen). Antibodies used for immunoblotting include MUS81 (Abcam, ab14387, 1 : 1000 dilution), Abraxas (homemade, 1 : 1000 dilution)23, SLX4 (Bethyl Laboratories, A302-269A,

(12) RADX prevents genome instability by confining replication fork reversal to stalled forksMolecular cellJuly 15, 2021Krishnamoorthy A, Jackson J, Mohamed T, Adolph M, Vindigni A, Cortez D.polyclonal RTEL1,Novus Biotechne,Cat#NBP2-22360;RRID: AB_2722642 Mouse monoclonal MUS81,Abcam,Cat# ab14387;RRID: AB_301167 Rabbit polyclonal Abro1,Abcam,Cat# ab83860;RRID: AB_1860658 Mouse monoclonal GAPDH,Chemicon/Millipore,Cat#

(13) EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restartMolecular cellJuly 15, 2021Hambarde S, Tsai CL, Pandita RK, Bacolla A, Maitra A, Charaka V, Hunt CR, Kumar R, Limbo O, Le Meur R, et al.,Santa Cruz Biotechnology,Cat# Sc-8432 Anti-Mre11 antibody,Bethyl Laboratories,Cat# A303–998A Anti-MUS81 antibody,Abcam,Cat# ab14387 Anti-DNA2 antibody,Abcam,Cat# ab197283 Anti-EXO1 antibody,Abcam,Cat# ab69874 Anti-FANCA antibody,Abcam,Cat#

(14) Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shorteningNature communicationsMarch 12, 2021Baxley RM, Leung W, Schmit MM, Matson JP, Yin L, Oram MK, Wang L, Taylor J, Hedberg J, Rogers CB, et al.(Santa Cruz G12, SC55568; 1:500), mouse anti-MCM4 (Santa Cruz G7, SC28317; 1:500), mouse anti-MUS81 (Abcam ab14387; 1:500), mouse anti-PCNA (Abcam Ab29; 1:3,000), rabbit anti-Ubiquityl-PCNA (Lys164) (Cell Signaling

(15) SLX4-XPF mediates DNA damage responses to replication stress induced by DNA-protein interactionsThe Journal of cell biologyJanuary 4, 2021Ishimoto R, Tsuzuki Y, Matsumura T, Kurashige S, Enokitani K, Narimatsu K, Higa M, Sugimoto N, Yoshida K, Fujita M.Mouse, sc-247), SLX4 (Novus; Rabbit, NBP1-28680), XPF (Bethyl; Rabbit, A301-315A), MUS81 (Abcam; Mouse, ab14387), SLX1 (Atlas Antibodies; Rabbit, HPA047038), PICH (clone 142–26-3, Merck, Mouse, 04–1540), goat normal

(16) PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient CellsMolecular cellOctober 15, 2020Kim JJ, Lee SY, Choi JH, Woo HG, Xhemalce B, Miller KM.,Novus Biologicals,Cat# NB100-304 Anti-MRE11 Antibody,Novus Biologicals,Cat# NB100-142 Anti-Mus81 Antibody,Abcam,Cat# ab14387 Anti-DNA2 Antibody,Abcam,Cat# ab96488 Anti-FAN1 Antibody,Abcam,Cat# ab68572 Anti-CtIP Antibody,Cell Signaling

(17) SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbationsNature Structural & Molecular BiologyMay 1, 2020A. Takedachi et al.antibody was produced by the laboratory of Arturo Londoño-Vallejo[64]. Mouse anti-MUS81 (MTA30 2G10/3; ab14387), mouse anti-GAPDH (ab9484), rabbit antiFANCD2 (ab2187) and rabbit anti-RNA pol II (ab5095; phospho

(18) ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback LoopMolecular cellFebruary 6, 2020Matos DA, Zhang JM, Ouyang J, Nguyen HD, Genois MM, Zou L.,Santa Cruz,sc-53275 GAPDH,Millipore,ABS16 GFP,Millipore,MAB2510 γH2AX,Millipore,05-636 HA,Abcam,ab18181 HLTF,Sana Cruz,sc-398357 KAP1 pS824,Bethyl,A300-767A MUS81,Abcam,ab14387 PCNA,Abcam,ab18197 PCNA,Santa Cruz,sc-56 Rad17,Abcam,ab151513 RECQ1,Bethyl,A300-450A RNAP II pSer2,Novus

(19) ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stressNature communicationsDecember 16, 2019Park SH, Kang N, Song E, Wie M, Lee EA, Hwang S, Lee D, Ra JS, Park IB, Park J, et al.anti-MCM2 (Abcam, ab4464, 1:2000); anti-pMCM2(S40/S41) (Bethyl, A300-788A, 1:2000); anti-MUS81 (Abcam, ab14387, 1:1000); anti-SLX4 (Abcam, ab169114, 1:1000); anti-DNA-PK (Thermo Scientific, MS-423-P1, 1:1000); anti-pDNA-PK(S2056)

(20) Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathwayScience AdvancesOctober 9, 2019Mafei Xu, Jun Qin, Leiming Wang, Hui-Ju Lee, Chung-Yang Kao, Dan Liu, Zhou Songyang, Junjie Chen, Ming-Jer Tsai, Sophia Y. TsaiMillipore, MABC557), anti-FANCI (rabbit, Bethyl Laboratories, A301-254A), anti-MUS81 (mouse, Abcam, ab14387), anti-SLX4 (rabbit, Bethyl Laboratories, A302-270A), anti–p-ATM (Ser1981) (mouse, EMD Millipore, 05-740),

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Anti-Mus81 antibody [MTA30 2G10/3] from Abcam

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Anti-Mus81 antibody [MTA30 2G10/3] from Abcam

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